SPIRAL ARTERIAL REMODELING IS NOT ESSENTIAL FOR NORMAL BLOOD PRESSURE REGULATION IN PREGNANT MICE

摘要: Maternal cardiovascular adaptations occur in normal pregnancy, systemically, and within the uterus. In humans, gestational control of blood pressure is clinically important. Transient structural remodeling endometrial spiral arteries normally occurs human mouse pregnancies. mice, this depends on uterine natural killer cell function. Using immune-deficient we asked whether artery critically regulates mean arterial and/or placental growth. Radiotelemetric transmitters were implanted females hemodynamic profiles to a dietary salt challenge pregnancy assessed. Implantation sites from noninstrumented used for histological morphometry. Both mice had sensitivity showed similar 5-phase patterns correlating with stages development, regardless modification. After implantation, declined during preplacental phase reach midgestation nadir. With gestation day 9 opening circulation, rose, reaching baseline before parturition, whereas heart rate dropped. Heart stabilized parturition. Placental sizes deviated late when growth stopped but continued mice. As an indication potential abnormal hemodynamics, 2 pregnant delivering dead offspring developed hypertension. This study characterizes dynamic pattern over that parallels gestation. Unexpectedly, these data reveal not required or