Thrombosis with outflow obstruction delays thrombolysis and results in chronic wall thickening of rat veins

摘要: Abstract Purpose: An in vivo model of acute deep venous thrombosis was developed rats to assess the role and outflow obstruction recanalization development secondary wall changes. Methods: The left femoral veins male Sprague-Dawley were thrombosed either by means proximal ligation (obstruction, group A, n = 38) or temporary 24-hour occlusion with a microvascular clamp (unobstructed, B, 20). Right served as controls. killed at intervals over 5 weeks. Wall thickness compared among groups counting cells on representative sections through midvein area. Thrombi indirectly quantitated radiolabeled fibrinogen assay parallel series rats. Results: Control showed no evidence cellular structural Early thrombus extension seen A (peak day 4) followed after 2 Group had marked thickening (27 ± 7 vs 6 cells, p Conclusions: Thrombosis rat without chronic results rapid lysis transient proliferative In contrast, delayed recanalization, early thrombus, vigorous persistent responses. Thrombus-induced may be an important factor postthrombotic insufficiency. (J Vasc Surg 1998;28:115-23.)