Micellization of Diblock(oxyethylene/oxybutylene) Copolymer E11B8 in Aqueous Solution. Micelle Size and Shape. Drug Solubilization

摘要: Copolymer E11B8 [E denotes OCH2CH2, B OCH2CH(C2H5), and the subscripts denote number-average chain lengths] was prepared by sequential oxyanionic polymerization characterized GPC (for distribution width) NMR spectroscopy absolute composition length). It studied as with hydroxyl groups terminating B-blocks (E11B8H) after methylation (E11B8M). Clouding temperatures were determined over a wide concentration range, critical micelle concentrations dye solubilization. Dynamic static light scattering used to characterize micelles demonstrate formation of compact at low which change large (probably wormlike) on heating solution within 10 °C clouding boundary. The solubilization griseofulvin (a drug poor water solubility) range temperature, effect size this property is discussed.