The myeloid lineage is required for the emergence of a regeneration-permissive environment following Xenopus tail amputation

摘要: Regeneration-competent vertebrates are considered to suppress inflammation faster than non-regenerating ones. Hence, understanding the cellular mechanisms affected by immune cells and can help develop strategies promote tissue repair regeneration. Here, we took advantage of naturally occurring tail regeneration-competent -incompetent developmental stages Xenopus tadpoles. We first establish essential role myeloid lineage for regeneration in then reveal that upon amputation there is a lineage-dependent change amputation-induced apoptosis levels, which turn promotes remodelling, ultimately leads relocalization regeneration-organizing responsible progenitor proliferation. These failed be executed regeneration-incompetent demonstrate incompetency characterized inflammatory whereas competency associated with reparative cells. Moreover, treatment tadpoles immune-suppressing drugs restores lineage-controlled mechanisms. Collectively, our work reveals effects differential activation on creation regeneration-permissive environment could further exploited devise regenerative medicine purposes.