Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia mangostana
作者： Sunit Suksamrarn , Narisara Suwannapoch , Wong Phakhodee , Janthana Thanuhiranlert , Piniti Ratananukul
DOI: 10.1248/CPB.51.857
关键词:
摘要: Prenylated xanthones, isolated from the fruit hulls and edible arils seeds of Garcinia mangostana, were tested for their antituberculosis potential. Alpha- beta-mangostins garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with minimum concentration (MIC) value 6.25 microg/ml. Tri- tetra-oxygenated xanthones di-C5 units or a C5 modified groups are essential high activities. Substitution in A C rings has been shown to modify bioactivity compounds.
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