Effects of enteral and intravenous antimicrobial treatment on survival following intestinal ischemia in rats.

摘要: One hundred and twenty rats underwent transection of the superior mesenteric artery. The animals were randomly divided into eight groups 15 animals. Control group 1 3, 5, 7 received intravenous normal saline, gentamicin, metronidazole, gentamicin plus respectively. 2 4, 6, 8 same compounds enterally. Small large bowel sections taken postmortem a necrosis score was assigned in blinded fashion. Gentamicin did not prolong survival, indicating that gram-negative microbes important this pathology. Longer survival times for given either metronidazole or (P less than 0.01) indicate anaerobes causative factor mortality. During first hr after ischemia, antibiotics change After hr, enteral administration to any regimen including 0.01).