Is Apolipoprotien E codon 112 Polymorphisms Associated with Recurrent Pregnancy Loss?
作者： Hakan Ozornek , Elif Ergin , Rajasingam S. Jeyendran , Alev T. Ozay , Delanie Pillai
DOI: 10.1111/J.1600-0897.2010.00814.X
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摘要: Citation Ozornek H, Ergin E, Jeyendran RS, Ozay AT, Pillai D, Coulam C. Is Apolipoprotien E codon 112 polymorphisms associated with recurrent pregnancy loss? Am J Reprod Immunol 2010; 64: 87–92 Problem To compare the prevalence of 112T>C point mutations among women experiencing RPL fertile control women. Method Study Buccal swabs were obtained from 232 individuals: 136 a history ≥2 abortions, 37 at least 2 live births and 59 deep vein thrombosis (DVT). DNA was extracted PCR amplification Apo codons performed. Results The allelic frequency cytosine position 11.4% (31/272) patients RPL, compared 5.4% (4/74) controls (P = 0.19) 19.5% (23/118) individuals DVT. However, significantly more E3/E4 E4/E4 genotypes seen DVT than (P < 0.05). Conclusion E4 112C mutation is, by itself, not an elevated risk loss, but rather in association 158C is factor for RPL.
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