Regulation of blood-testis barrier (BTB) dynamics during spermatogenesis via the "Yin" and "Yang" effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2.

摘要: Abstract In mammalian testes, haploid spermatozoa are formed from diploid spermatogonia during spermatogenesis, which is a complicated cellular process. While these events were reported in the 1960s and 1970s, underlying molecular mechanism(s) that regulates remained unexplored until past ∼10 years. For instance, adhesion proteins shown to be integrated components at Sertoli cell–cell interface and/or Sertoli–spermatid late 1980s. But only recently, studies have demonstrated some of serve as platform for signal transduction cell adhesion. this chapter, brief summary critical discussion provided on latest findings regarding cell-adhesion testis their relationship spermatogenesis. Moreover, antagonistic effects two target rapamycin (mTOR) complexes, known mTORC1 mTORC2, function discussed. Finally, hypothetic model presented depict how mTOR-signaling complexes having “yin” “yang” tight junction (TJ)-permeability barrier can maintain blood–testis (BTB) integrity epithelial cycle while preleptotene spermatocytes crossing BTB.