New insights into the hepatitis E virus genotype 3 phylodynamics and evolutionary history.

摘要: Hepatitis E virus (HEV) is an emergent hepatotropic endemic mainly in Asia and other developing areas. However, the last decade it has been increasingly reported high-income countries. Human infecting HEV strains are currently classified into four genotypes (1-4). Genotype 3 (HEV-3) prevalent genotype mostly associated with autochthonous sporadic cases of developed The evolutionary history worldwide remains largely unknown. In this study we reconstructed spatiotemporal population dynamics HEV-3 at global scale, but particular emphasis South America, where case reports have increased dramatically years. To achieve this, applied a Bayesian coalescent-based approach to comprehensive data set comprising 97 GenBank sequences for which location sampling date was documented. Our phylogenetic analyses suggest that genetic diversity can be grouped two main Clades (I II) Ƭmrca dated approximately 320years ago (95% HPD: 420-236years) unique independent introduction seems occurred Uruguay, most human America described. phylodynamic inference indicates size suffered substantial temporal variations after second half 20th century. sense conversely what postulated date, effective not decreasing frequently sources error its estimates stem from assumptions analyzed derived single panmictic population. Novel insights on given. Additionally, work constitutes attempt further describe coalescent framework, phylodynamics American region.