Predictors for Glucose Change in Hypertensive Participants Following Short-term Treatment with Atenolol or Hydrochlorothiazide

摘要: The hyperglycemia associated with the most commonly prescribed antihypertensive drug classes is of growing concern to medical community. It well documented that β-blockers and thiazide diuretics cause adverse metabolic effects, large-scale studies meta-analyses provide compelling data indicating increase risk diabetes.1–5 The ability discern which participants are at greatest for or development diabetes would be valuable clinicians4,6–9. Previous found African ancestry, higher body mass index, left ventricular hypertrophy, follow-up systolic blood pressure, elevated baseline glucose, uric acid, female sex, age after long-term β-blocker and/or diuretic therapy. 3, 4, 10, 11 One study lower urinary sodium excretion were significant predictors change in glucose hydrochlorothiazide (HCTZ) monotherapy.12 To date, no have evaluated β-blockers. Given use may offset clinical benefit these two classes,10, 13–15 it important identify characteristics risk. If such factors could identified, they might useful guide selection Therefore, goal current was determine impaired fasting (IFG) following treatment atenolol HCTZ.