Proinflammatory status, genetics and atherosclerosis.

摘要: Over the last decade, C-reactive protein concentration analyzed by high sensitivity method (hsCRP) has been proven as a marker of premature atherosclerosis. Concentration exceeding 2 mg/l represents an increased individual risk myocardial infarction and stroke but strict application this borderline is complicated relations CRP concentrations to other factors cardiovascular diseases. In large 1 % representative sample Czech population, positive relation hsCRP BMI, waist circumference triglyceride was documented. Substantial sex differences were found in its relationship age. Whereas it continuously increasing men, increase appears women only after menopause. A substantial decrease body weight visceral fat volume physical activity accompanied significant young obese women. This not related change interleukin-6 concentration, although supposed regulate production. partly under genetic control higher siblings probands with proved coronary atherosclerosis The participation genes lipoprotein metabolism (genes for apolipoprotein CI E) influence concentrations. We hypothesized that certain proinflammatory status central obesity might be properties monocytes atherogenesis.