Pancreatic Cholera: Beneficial Effects of Treatment with Streptozotocin

摘要: Abstract Two patients with pancreatic cholera and islet-cell carcinoma were treated intra-arterial streptozotocin. Before therapy, they had stool volumes from 2 to 8 liters per day required 200 800 mEq of supplemental potassium. After three five doses streptozotocin (1.5 g square meter), both volume number size hepatic metastases decreased markedly. One patient has normally formed stools for 12 months; the other a 90 cent reduction in 13 months additional therapy. Both patients' serum potassium returned normal without need supplementation. Jejunal adenylate cyclase activity was both, plasma vasoactive intestinal peptide detectable only one. chemotherapy, these findings showed no consistent change. Pharmacologic studies suggest that arterial administration increased either tumor or extraction (or both) by two times renal exposure this nephrotoxic drug...