Diazepam dissociates the analgesic and aversive effects of periaqueductal gray stimulation in the rat
作者： Michael M. Morgan , Antoine Depaulis , John C. Liebeskind
DOI: 10.1016/0006-8993(87)90870-5
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摘要: Electrical stimulation of the periaqueductal gray matter (PAG) rat can produce both analgesia and aversive reactions. To determine if these two effects be dissociated, diazepam, a benzodiazepine, was administered to rats chronically implanted with electrodes in PAG. The threshold for stimulation-produced or aversion, whichever lowest, determined before after drug administration. Diazepam (1 mg/kg) attenuated reactions at 12 20 sites, allowing measured same threshold. did not alter baseline pain sensitivity thresholds analgesia. These results indicate that from PAG pharmacologically dissociated.
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