Effect of vascular targeting agent in rat tumor model: dynamic contrast-enhanced versus diffusion-weighted MR imaging.
作者： Harriet C. Thoeny , Frederik De Keyzer , Vincent Vandecaveye , Feng Chen , Xihe Sun
DOI: 10.1148/RADIOL.2372041638
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摘要: PURPOSE: To compare dynamic contrast material–enhanced magnetic resonance (MR) imaging and diffusion-weighted MR for noninvasive evaluation of early late effects a vascular targeting agent in rat tumor model. MATERIALS AND METHODS: The study protocol was approved by the local ethics committee animal care use. Thirteen rats with one rhabdomyosarcoma each flank (26 tumors) underwent contrast-enhanced echo-planar 1.5-T unit before intraperitoneal injection combretastatin A4 phosphate at (1 6 hours) later (2 9 days) follow-up examinations after injection. Histopathologic examination performed time point. apparent diffusion coefficient (ADC) calculated separately on basis images obtained low b gradient values (ADClow; = 0, 50, 100 sec/mm2) high (ADChigh; 500, 750, 1000 sec/mm2). difference between...
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