Stem Cell Characters in Primary and Metastatic Tumour Establishment

摘要: Continuously increasing evidence has shown that most primary tumours contain subpopulations of cells with stem-like characteristics and their existence is associated resistance to therapy formation metastases at distant sites. This further supported by the identification several common key pathways genes between cancer normal stem involved mainly in proliferation, differentiation de-differentiation steps. Cancer (CSCs) can self-renew as well give rise non-CSC progeny. CSCs may exist within tumour since early stages or develop during progression through developmental process epithelial-to-mesenchymal transition (EMT). Cells features have been recently identified circulating (CTCs) are responsible for generation metastases. Dissemination from occur development later progression. Here, we review current knowledge concerning CSCs’ development, metastatic potential, implications mechanisms govern these processes, including molecular role microenvironment.