Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states
作者： Anya Medina , Yuko Nakagawa , Jinhui Ma , Longfei Li , Kunihisa Hamano
DOI: 10.1507/ENDOCRJ.EJ14-0221
关键词:
摘要: We reported recently that the taste type 1 receptor 3 (T1R3), a subunit of sweet receptor, functions as cell-surface glucose-sensing in pancreatic β-cells. In present study, we investigated expression T1R3 islets. mRNA for T1R2 and was detected mouse Quantitatively, level less than 1% T1R3. Immunohistochemically, abundantly expressed islets whereas barely detected. Most immunoreactive colocalized with insulin almost all β-cells were positive addition, some portion α-cells. Immunoreactivity markedly reduced fed mice compared to those fasting mice. contrast, not different Glucose-induced insulin-secretion higher obtained from The ob/ob control Similarly, islet db/db fatty diabetic rats GK rats, models obese non-obese 2 diabetes, respectively. These results indicate is mainly levels are depending upon nutritional metabolic conditions.
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