Characterization of a novel congenic strain of diabetic fatty (WBN/Kob-Leprfa) rat
作者： Toshio Akimoto , Kazumasa Nakama , Yasumi Katsuta , Xue-Jun Zhang , Masaru Ohsuga
DOI: 10.1016/J.BBRC.2007.12.003
关键词: Obesity 、 Leptin Receptor Gene 、 Internal medicine 、 Pancreas 、 Congenic 、 Pancreatitis 、 Diabetes mellitus 、 Allele 、 Leptin receptor 、 Medicine 、 Endocrinology 、 Biophysics 、 Cell biology 、 Biochemistry 、 Molecular biology
摘要: Abstract The WBN/Kob- Lepr fa rat is a new congenic strain for the allele of leptin receptor gene ( ). Homozygous / ) rats provide model non-insulin-dependent diabetes with obesity. Here, we describe characteristics this animal in detail. At 7 weeks age, both male and female obese WBN/Kob showed inflammatory cell infiltration pancreas that suggested pan-pancreatitis an abnormal OGTT. 3 months developed overt mellitus associated severe chronic pancreatitis. In contrast, lean do not develop pancreatitis or diabetes. rats, mutation might promote onset pancreatitis, leading to rapid development mellitus.
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sci-hub.se 参考文章(27)
O E Michaelis, K C Ellwood, J M Judge, N W Schoene, C T Hansen, Effect of dietary sucrose on the SHR/N-corpulent rat: a new model for insulin-independent diabetes The American Journal of Clinical Nutrition. ,vol. 39, pp. 612- 618 ,(1984) , 10.1093/AJCN/39.4.612
Taku MASUYAMA, Yoshiaki KATSUDA, Masami SHINOHARA, A Novel Model of Obesity-Related Diabetes: Introgression of the Leprfa Allele of the Zucker Fatty Rat into Nonobese Spontaneously Diabetic Torii (SDT) Rats Experimental Animals. ,vol. 54, pp. 13- 20 ,(2005) , 10.1538/EXPANIM.54.13
Kazumasa Nakama, Kazuhiro Shichinohe, Kazuo Kobayashi, Katsushi Naito, Osayuki Uchida, Kazuo Yasuhara, Masuo Tobe, Spontaneous diabetes-like syndrome in WBN/KOB rats. Acta Diabetologica. ,vol. 22, pp. 335- 342 ,(1985) , 10.1007/BF02624752
Takashi Hashimoto, Tamaki Yamada, Takio Yokoi, Hitoshi Sano, Hakuji Ando, Takahiro Nakazawa, Hirotaka Ohara, Tomoyuki Nomura, Takashi Joh, Makoto Itoh, Apoptosis of acinar cells is involved in chronic pancreatitis in Wbn/Kob rats: role of glucocorticoids. Pancreas. ,vol. 21, pp. 296- 304 ,(2000) , 10.1097/00006676-200010000-00012
Juan Martínez, José Sánchez-Payá, José M Palazón, José R Aparicio, Antonio Picó, Miguel Pérez-Mateo, None, Obesity: a prognostic factor of severity in acute pancreatitis. Pancreas. ,vol. 19, pp. 15- 20 ,(1999) , 10.1097/00006676-199907000-00002
I. C. Funnell, P. C. Bornman, S. P. Weakley, J. Terblanche, I. N. Marks, Obesity: an important prognostic factor in acute pancreatitis British Journal of Surgery. ,vol. 80, pp. 484- 486 ,(2005) , 10.1002/BJS.1800800426
B. L. Leonard, R. N. Watson, K. M. Loomes, A. R. J. Phillips, G. J. Cooper, Insulin resistance in the Zucker diabetic fatty rat : a metabolic characterisation of obese and lean phenotypes Acta Diabetologica. ,vol. 42, pp. 162- 170 ,(2005) , 10.1007/S00592-005-0197-8
Lois M. Zucker, HEREDITARY OBESITY IN THE RAT ASSOCIATED WITH HYPERLIPEMIA Annals of the New York Academy of Sciences. ,vol. 131, pp. 447- 458 ,(1965) , 10.1111/J.1749-6632.1965.TB34810.X
Ming-Xian Yan, Yan-Qing Li, Min Meng, Hong-Bo Ren, Yi Kou, Long-term high-fat diet induces pancreatic injuries via pancreatic microcirculatory disturbances and oxidative stress in rats with hyperlipidemia Biochemical and Biophysical Research Communications. ,vol. 347, pp. 192- 199 ,(2006) , 10.1016/J.BBRC.2006.06.063
JOHN L CAMERON, DAVID M. CAPUZZI, GEORGE D. ZUIDEMA, SIMEON MARGOLIS, Acute pancreatitis with hyperlipemia: the incidence of lipid abnormalities in acute pancreatitis. Annals of Surgery. ,vol. 177, pp. 483- 489 ,(1973) , 10.1097/00000658-197304000-00017