Evolution of Vertebrate Voltage-Gated Ion Channel α Chains by Sequential Gene Duplication

摘要: Phylogenetic analysis of alpha chains voltage-gated ion channels revealed that extensive gene duplication has occurred among both Ca(2+) and Na(+)-channels since the origin vertebrates. Rather than showing a pattern consistent with hypothesis polyploidization early in vertebrate history, Na(+) showed patterns sequential associated specialization products. In case channels, phylogeny supported ancestral had an expression including central peripheral nervous system cells channel genes repeatedly been followed by for system, or muscle cells. Thus, cephalization evolution accompanied this important family neuromuscular proteins along central-peripheral axis.