Positive selection on protein-length in the evolution of a primate sperm ion channel.

摘要: Positive Darwinian selection on advantageous point substitutions has been demonstrated in many genes. We here provide empirical evidence, for the first time, that positive can also act insertion/deletion (indel) evolution of a protein. CATSPER1 is voltage-gated calcium channel found exclusively plasma membrane mammalian sperm tail and it essential motility. determined DNA sequences exon gene from 15 primates, which encodes intracellular N terminus region ≈400 aa. These exhibit an excessively high frequency indels. However, all indels have lengths are multiples 3 nt (3n indels) do not disrupt ORF. The number indel per site year five to eight times corresponding rates calculated two large-scale primate genomic comparisons, represent neutral rate substitutions. Moreover, considerably longer than observations strongly suggest promoting fixation mutations 1. It shown certain ion channels length affects inactivation. This finding suggests detected may be related regulation channel, affect motility, important determinant competition.