Cerebral phaeohyphomycosis: Case report

摘要: Cerebral phaeohyphomycosis is a rare and frequently fatal disease. This disease often caused by hematogenous spread of pathogens that are inoculated in the skin extremities after slight or minor trauma, its mortality rate rather high despite aggressive treatment. Our patient presented with headache pyrexia. She was diagnosed fungal meningitis treated systemic administration voriconazole (VRCZ). However, initial improvement, recurred. MRI brain showed multiple small masses cerebral hemisphere she thus referred to our Department Neurosurgery. On admission, an examination were deeply located too be excised; therefore, treatment VRCZ intrathecal amphotericin B initially selected. intracerebral continued grow; they surgically excised. Histological surgical specimens at time identified as granuloma infection Aspergillus niger. After surgery, her general condition improved; therefore antifungal agents continued. recurred, further administration, died 43 months diagnosis. Autopsy lesions phaeohyphomycotic granulomas. paper describes clinical presentation, histopathological results for this