Seizure-Induced Neuronal Plasticity and Metabolic Effects

摘要: Epilepsy, the most common acquired chronic neurological disease, occurs in 1% of human population. Despite treatment with newest antiepileptic medications, almost one-third individuals continue having seizures (Kwan and Brodie, 2000). Many those seizure persistence even some ­remittance suffer often from under-appreciated co-morbidities including cognitive deficits psychopathology such as anxiety, depression, poor attention. Our understanding epileptogenesis its concurrent effects is based mainly on animal models. Using humans epilepsy to study fraught multiple problems ethics, medication effects, reproducibility. More recently, however, brain tissue surgical ­resections has been studied (this represents only a small subgroup patients epilepsy). Modern imaging techniques have also helped unveil widespread metabolic ­abnormalities associated epilepsy.