Association Between Genetic Variation in the SCN10A Gene and Cardiac Conduction Abnormalities in Patients With Hypertrophic Cardiomyopathy.

摘要: Arrhythmias are associated with reduced quality of life and poor prognosis in patients hypertrophic cardiomyopathy (HCM). Recent genome-wide association studies revealed that a nonsynonymous single nucleotide polymorphism, rs6795970, the SCN10A gene was PR interval. We examined whether prolonging allele (A allele) may be cardiac conduction abnormalities HCM patients.We genotyped polymorphism 149 patients. Conduction were defined as first-degree heart block, bundle-branch bifascicular block. Patients divided into two groups: group A consisted 122 (82%) without abnormality; B 27 (18%) one or more abnormalities. The frequency distribution genotypes (G/G, G/A, A/A) among 71%, 26%, 3%, respectively. abnormality documented 9% G/G 40% G/A A/A. There significant difference genotype between groups (P = 0.0002). In dominant model, there < 0.0001). addition, remained after adjusting for other covariates multivariate model (odds ratio 6.30 [95% confidence interval: 2.24 to 19.09], P 0.0005).The rs6795970 gene, which is reported carry high risk might