Asiatic Acid Decreases Blood Pressure and Oxidative Stress Markers in L-NAME-induced Hypertensive Rats
作者： Sarawoot Bunbupha , Dr. Poungrat Pakdeechote , Dr. Upa Kukongviriyapan , Dr.Parichat Prachaney
DOI: 10.5481/KKUJGS.2013.13.3.4
关键词:
摘要: This study aimed to investigate the effect of asiatic acid on blood pressure and oxidative stress status in N-nitro-L-arginine-methylester (L-NAME) induced hypertensive rats. Daily administration L-NAME (40 mg/kg) male Sprague-Dawley rats for 5 weeks showed significant increases systolic (SP), vascular superoxide production, plasma heart tissue malondialdehyde (MDA) (p<0.05). However, supplementation (20 or L-arginine (100 2 significantly reduced elevation SP, markers (p<0.05) treated suggests that had an anti-hypertensive effects with its is likely be linked alleviation status. บทคดยอ การศกษานมวตถประสงคเพอศกษาผลของสารเอเชยตก แอซด ตอความดนเลอดและภาวะเครยด ออกซเดชน ในหนขาวความดนเลอดสงทถกเหนยวน�าดวยสารแอลเนม ผลการทดลองพบวาหนทดลองทได รบสารแอลเนม มก./กก.) เปนเวลา สปดาห มการเพมขนของความดนเลอด การผลต ในหลอดเลอด ระดบของ ในพลาสมาและเนอเยอหวใจ อยางไรกตาม การใหเอเชยตก หรอ สามารถลด ระดบความดนเลอด และสารบงชภาวะเครยดออกซเดชน ในหนทดลองความดนเลอดสง การศกษา ครงนแสดงใหเหนวา เอเชยตก มฤทธตานความดนเลอดสงในหนทดลองทไดรบแอลเนม โดยผลดงกลาว อาจจะมความสมพนธกบการลดลงของภาวะเครยดออกซเดชน
sci-hub.st 参考文章(17)
G A Rongen, T Thien, P Smits, Endothelium and the regulation of vascular tone with emphasis on the role of nitric oxide. Physiology, pathophysiology and clinical implications. Netherlands Journal of Medicine. ,vol. 44, pp. 26- 35 ,(1994)
Andréia Machado Cardoso, Caroline Curry Martins, Fernando da Silva Fiorin, Roberta Schmatz, Fátima Husein Abdalla, Jessié Gutierres, Daniela Zanini, Amanda Maino Fiorenza, Naiara Stefanello, Jonas Daci da Silva Serres, Fabiano Carvalho, Verônica Paiva Castro, Cinthia Melazzo Mazzanti, Luiz Fernando Freire Royes, Adriane Belló-Klein, Jeferson Ferraz Goularte, Vera Maria Morsch, Margarete Dulce Bagatini, Maria Rosa Chitolina Schetinger, Physical training prevents oxidative stress in L-NAME-induced hypertension rats. Cell Biochemistry and Function. ,vol. 31, pp. 136- 151 ,(2013) , 10.1002/CBF.2868
Shyh-Shyun Huang, Chuan-Sung Chiu, Hsien-Jung Chen, Wen-Chi Hou, Ming-Jyh Sheu, Ying-Chih Lin, Pei-Hsin Shie, Guan-Jhong Huang, Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. Evidence-based Complementary and Alternative Medicine. ,vol. 2011, pp. 895857- 895857 ,(2011) , 10.1155/2011/895857
Vito De Gennaro Colonna, Antonello Rigamonti, Simona Fioretti, Sara Bonomo, Barbara Manfredi, Paolo Ferrario, Mauro Bianchi, Ferruccio Berti, Eugenio E. Muller, Giuseppe Rossoni, Angiotensin-converting enzyme inhibition and angiotensin AT1-receptor antagonism equally improve endothelial vasodilator function in l-NAME-induced hypertensive rats European Journal of Pharmacology. ,vol. 516, pp. 253- 259 ,(2005) , 10.1016/J.EJPHAR.2005.04.004
J F Arnal, A I el Amrani, G Chatellier, J Ménard, J B Michel, Cardiac weight in hypertension induced by nitric oxide synthase blockade. Hypertension. ,vol. 22, pp. 380- 387 ,(1993) , 10.1161/01.HYP.22.3.380
Saowanee Nakmareong, Upa Kukongviriyapan, Poungrat Pakdeechote, Wanida Donpunha, Veerapol Kukongviriyapan, Bunkerd Kongyingyoes, Kwanjit Sompamit, Chada Phisalaphong, Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with l-NAME-induced hypertension Naunyn-Schmiedeberg's Archives of Pharmacology. ,vol. 383, pp. 519- 529 ,(2011) , 10.1007/S00210-011-0624-Z
Kuifen Ma, Yuyu Zhang, Danyan Zhu, Yijia Lou, Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway European Journal of Pharmacology. ,vol. 603, pp. 98- 107 ,(2009) , 10.1016/J.EJPHAR.2008.11.054
Yong Soo Lee, Da-Qing Jin, Sung-Mok Beak, Eung-Seok Lee, Jung-Ae Kim, Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes. European Journal of Pharmacology. ,vol. 476, pp. 173- 178 ,(2003) , 10.1016/S0014-2999(03)02177-0
Iveta Bernátová, Ol’ga Pechánová, František Kristek, Mechanism of structural remodelling of the rat aorta during long-term NG-nitro-L-arginine methyl ester treatment. Japanese Journal of Pharmacology. ,vol. 81, pp. 99- 106 ,(1999) , 10.1254/JJP.81.99
R D Manning, L Hu, H L Mizelle, J P Montani, M W Norton, Cardiovascular responses to long-term blockade of nitric oxide synthesis. Hypertension. ,vol. 22, pp. 40- 48 ,(1993) , 10.1161/01.HYP.22.1.40