Physical training prevents oxidative stress in L-NAME-induced hypertension rats.
作者： Andréia Machado Cardoso , Caroline Curry Martins , Fernando da Silva Fiorin , Roberta Schmatz , Fátima Husein Abdalla
DOI: 10.1002/CBF.2868
关键词:
摘要: The present study investigated the effects of a 6-week swimming training on blood pressure, nitric oxide (NO) levels and oxidative stress parameters such as protein lipid oxidation, antioxidant enzyme activity endogenous non-enzymatic content in kidney circulating fluids, well serum biochemical (cholesterol, triglycerides, urea creatinine) from Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertension treated rats. Animals were divided into four groups (n = 10): Control, Exercise, L-NAME Exercise L-NAME. Results showed that exercise prevented decrease NO hypertensive rats (P < 0·05). An increase oxidation observed L-NAME-treated group was reverted by physical A catalase (CAT) superoxide dismutase (SOD) activities when compared with normotensive In kidney, significantly augmented CAT SOD There non-protein thiols (NPSH) group, there an NPSH elevation cholesterol, creatinine to close normal had hypotensive effect, reducing pressure These findings suggest could have protector effect against damage renal injury caused hypertension. Copyright © 2012 John Wiley & Sons, Ltd.
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