(−)-Epicatechin prevents alterations in the metabolism of superoxide anion and nitric oxide in the hearts of L-NAME-treated rats

作者: Barbara Piotrkowski , Valeria Calabró , Mónica Galleano , César G. Fraga

DOI: 10.1039/C4FO00554F

关键词: Nitric oxideInternal medicineSuperoxideSteady state (chemistry)Redox statusEndocrinologyMetabolismIn vivoPhosphorylationChemistryProtein subunit

摘要: The aim of this work was to evaluate the effects (−)-epicatechin administration in heart a rat model with reduced NO production that follows short-term treatment L-NAME. Sprague-Dawley rats were treated for 4 d L-NAME absence or presence diet. redox status cardiac tissue improved by administration. induced decrease synthase activity (−62%, p < 0.05) and an increase NADPH-dependent superoxide anion (+300%, totally prevented These associated higher endothelial phosphorylation at activation site expression regulatory subunit, p47phox, suggesting involvement posttranslational mechanisms action. Thus, would restore steady state levels vivo through on both, its synthesis degradation via reaction anion. fact is commonly present human diet makes compound reasonable explanation positive cardiovascular high consumption fruits vegetables.

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