Immunolocalization of β2-Glycoprotein I (Apolipoprotein H) to Human Atherosclerotic Plaques Potential Implications for Lesion Progression

作者: Jacob George , Dror Harats , Boris Gilburd , Arnon Afek , Yair Levy

DOI: 10.1161/01.CIR.99.17.2227

关键词:

摘要: Background—β2-Glycoprotein I (β2GPI) is a major antigenic target of antiphospholipid antibodies, which possesses natural anticoagulant properties. The aim the present study was to determine its ...

参考文章(12)
Robert A. S. Roubey, Immunology of the antiphospholipid antibody syndrome. Arthritis & Rheumatism. ,vol. 39, pp. 1444- 1454 ,(1996) , 10.1002/ART.1780390903
R Simantov, J M LaSala, S K Lo, A E Gharavi, L R Sammaritano, J E Salmon, R L Silverstein, Activation of cultured vascular endothelial cells by antiphospholipid antibodies. Journal of Clinical Investigation. ,vol. 96, pp. 2211- 2219 ,(1995) , 10.1172/JCI118276
Jacob George, Miri Blank, Yair Levy, Pierluigi Meroni, Maya Damianovich, Angela Tincani, Yehuda Shoenfeld, Differential Effects of Anti–β2-Glycoprotein I Antibodies on Endothelial Cells and on the Manifestations of Experimental Antiphospholipid Syndrome Circulation. ,vol. 97, pp. 900- 906 ,(1998) , 10.1161/01.CIR.97.9.900
Y. HASUNUMA, E. MATSUURA, Z. MAKITA, T. KATAHIRA, S. NISHI, T. KOIKE, Involvement of β2‐glycoprotein I and anticardiolipin antibodies in oxidatively modified low‐density lipoprotein uptake by macrophages Clinical and Experimental Immunology. ,vol. 107, pp. 569- 573 ,(1997) , 10.1046/J.1365-2249.1997.00300.X
Georg Wick, Georg Schett, Albert Amberger, Roman Kleindienst, Qingbo Xu, None, Is atherosclerosis an immunologically mediated disease Immunology Today. ,vol. 16, pp. 27- 33 ,(1995) , 10.1016/0167-5699(95)80067-0
A E Gharavi, L R Sammaritano, J Wen, K B Elkon, Induction of antiphospholipid autoantibodies by immunization with beta 2 glycoprotein I (apolipoprotein H). Journal of Clinical Investigation. ,vol. 90, pp. 1105- 1109 ,(1992) , 10.1172/JCI115927
Russell Ross, The pathogenesis of atherosclerosis: a perspective for the 1990s Nature. ,vol. 362, pp. 801- 809 ,(1993) , 10.1038/362801A0
S. Stemme, B. Faber, J. Holm, O. Wiklund, J. L. Witztum, G. K. Hansson, T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 3893- 3897 ,(1995) , 10.1073/PNAS.92.9.3893
Eric A. Jaffe, Ralph L. Nachman, Carl G. Becker, C. Richard Minick, Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA Journal of Clinical Investigation. ,vol. 52, pp. 2745- 2756 ,(1973) , 10.1172/JCI107470
J.L Witztum, The oxidation hypothesis of atherosclerosis The Lancet. ,vol. 344, pp. 793- 795 ,(1994) , 10.1016/S0140-6736(94)92346-9