Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib.
作者： Mario E. Lacouture , Shenhong Wu , Caroline Robert , Michael B. Atkins , Heidi H. Kong
DOI: 10.1634/THEONCOLOGIST.2008-0131
关键词:
摘要: The multitargeted kinase inhibitors (MKIs) sorafenib and sunitinib have shown benefit in patients with renal cell carcinoma, hepatocellular carcinoma (sorafenib), gastrointestinal stromal tumor (sunitinib). Their efficacy other malignancies is currently being investigated because of their broad range activity. effectiveness these drugs somewhat diminished by the development a variety toxicities, most notably hand-foot skin reaction (HFSR). Although HFSR does not appear to directly affect survival, it can impact quality life lead MKI dose modification or interruption, potentially limiting antitumor effect. Currently, no standard guidelines exist for prevention management MKI-associated HFSR. To address this issue, an international, interdisciplinary panel experts gathered January 2008 discuss evaluate best-practice reactions. Based on proceedings, recommendations been provided offer best possible while taking optimize patient associated therapy.
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