How could the Gompertz-Makeham law evolve.

摘要: Abstract In line with the origin of life from chemical world, biological mortality kinetics is suggested to originate decomposition described by Arrhenius equation k=A*exp(−E/RT). Another legacy living bodies that, using appropriate properties their constituent molecules, they incorporate all potencies, including adverse ones. early evolution, acquiring an ability use new molecules increase disintegration barrier E might be associated interactions, yielding products that accumulate in organisms and compromise viability. Thus, main variable changed T chemistry biology; turned rise exponentially as declined increasing age; survivorship patterns feature slow initial fast late descent making bulk each finite cohort expire within a short final period its lifespan. Numerical modelling shows such acquisition functions faster functional decline may efficiency investing resources into progeny, antagonistic pleiotropy theory ageing. Any evolved time trajectories changes were translated through exponent according generalised Gompertz–Makeham law μ=C(t)+Λ*exp[−E(t)], which reduced conventional form when E(t)=E0−γt C constant. The proposed model explains linear mid-age followed deceleration at later ages positive correlation between vitality rate