Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus.
作者： Mi-Hyeon Jang , Min-Chul Shin , Sae-Bin Jung , Taeck-Hyun Lee , Geon-Ho Bahn
DOI: 10.1097/00001756-200208270-00004
关键词:
摘要: It is generally accepted that alcohol and nicotine affect learning ability memory functions, especially in adolescents. In the present study, effects of on cell proliferation apoptosis dentate gyrus young rats were investigated. The results show suppressed by nicotine. Furthermore, increase number terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive cells. Based presented this it can be suggested alcohol- nicotine-related impairment functions may due to nicotine-induced suppression new formation acceleration apoptosis, during adolescence.
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sci-hub.se 参考文章(23)
Tracey J. Shors, George Miesegaes, Anna Beylin, Mingrui Zhao, Tracy Rydel, Elizabeth Gould, Neurogenesis in the adult is involved in the formation of trace memories Nature. ,vol. 410, pp. 372- 376 ,(2001) , 10.1038/35066584
Djoher Nora Abrous, Walter Adriani, Marie-Françoise Montaron, Catherine Aurousseau, Geneviève Rougon, Michel Le Moal, Pier Vincenzo Piazza, Nicotine Self-Administration Impairs Hippocampal Plasticity The Journal of Neuroscience. ,vol. 22, pp. 3656- 3662 ,(2002) , 10.1523/JNEUROSCI.22-09-03656.2002
Gerald M. COHEN, Caspases: the executioners of apoptosis Biochemical Journal. ,vol. 326, pp. 1- 16 ,(1997) , 10.1042/BJ3260001
Francois Berger, Fred H Gage, Sukumar Vijayaraghavan, None, Nicotinic Receptor-Induced Apoptotic Cell Death of Hippocampal Progenitor Cells The Journal of Neuroscience. ,vol. 18, pp. 6871- 6881 ,(1998) , 10.1523/JNEUROSCI.18-17-06871.1998
Usha Narayanan, Sanjay Birru, Julia Vaglenova, Charles R. Breese, Nicotinic receptor expression following nicotine exposure via maternal milk. Neuroreport. ,vol. 13, pp. 961- 963 ,(2002) , 10.1097/00001756-200205240-00012
John W. Olney, Tatyana Tenkova, Krikor Dikranian, Louis J. Muglia, Walter J. Jermakowicz, Cleta D'Sa, Kevin A. Roth, Ethanol-induced caspase-3 activation in the in vivo developing mouse brain. Neurobiology of Disease. ,vol. 9, pp. 205- 219 ,(2002) , 10.1006/NBDI.2001.0475
Manfred Biebl, Christiana M. Cooper, Jürgen Winkler, H.Georg Kuhn, Analysis of neurogenesis and programmed cell death reveals a self-renewing capacity in the adult rat brain Neuroscience Letters. ,vol. 291, pp. 17- 20 ,(2000) , 10.1016/S0304-3940(00)01368-9
Jeffrey D. Macklis, Neurobiology: New memories from new neurons. Nature. ,vol. 410, pp. 314- 317 ,(2001) , 10.1038/35066661
C. Thompson, Apoptosis in the pathogenesis and treatment of disease Science. ,vol. 267, pp. 1456- 1462 ,(1995) , 10.1126/SCIENCE.7878464
Elizabeth Gould, Patima Tanapat, Stress and hippocampal neurogenesis Biological Psychiatry. ,vol. 46, pp. 1472- 1479 ,(1999) , 10.1016/S0006-3223(99)00247-4