ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood–testes barrier function and testicular immune privilege
作者： C. M. K. MORROW , C. E. HOSTETLER , M. D. GRISWOLD , M.-C. HOFMANN , K. M. MURPHY
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摘要: The transcription factor Ets-variant gene 5 (ETV5) is essential for spermatogonial stem cell (SSC) self-renewal, as the targeted deletion of Etv5 in mice (Etv5 -/- ) results only first wave spermatogenesis. Reciprocal transplants neonatal germ cells from wild-type (WT) and testes were performed to determine role ETV5 Sertoli cells. appears be needed both types normal In addition, recipients displayed increased interstitial inflammation tubular involution after transplantation. Preliminary studies suggest that blood-testis barrier (Sertoli-Sertoli tight junctional complex) abnormal mouse.
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