Expression of fourteen novel obesity-related genes in zucker diabetic fatty rats
作者： Peter M Schmid , Iris Heid , Christa Buechler , Andreas Steege , Markus Resch
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摘要: Genome-wide association studies (GWAS) are useful to reveal an between single nucleotide polymorphisms and different measures of obesity. A multitude new loci has recently been reported, but the exact function most according genes is not known. The aim our study was start elucidating some these genes. We performed expression analysis fourteen genes, namely BDNF, ETV5, FAIM2, FTO, GNPDA2, KCTD15, LYPLAL1, MCR4, MTCH2, NEGR1, NRXN3, TMEM18, SEC16B TFAP2B, via real-time RT-PCR in adipose tissue kidney capsule, mesenterium subcutaneum as well hypothalamus obese Zucker diabetic fatty (ZDF) lean (ZL) rats at age 22 weeks. All target except for showed highest hypothalamus. This suggests a critical role obesity-related central regulation energy balance. Interestingly, pattern no differences ZDF ZL rats. However, FAIM2 were significantly lower expressed fat than NEGR1 even subcutaneous mesenterial fat, while MTCH2 higher investigated obesity implies them balance, also itself. For development phenotype peripheral rather mechanisms seem be relevant.
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Frank B Hu, Cuilin Zhang, Edwina Yeung, Lu Qi, Novel abdominal adiposity genes and the risk of type 2 diabetes: findings from two prospective cohorts. International journal of molecular epidemiology and genetics. ,vol. 2, pp. 138- 144 ,(2011)
Hermine HM Maes, Michael C Neale, Lindon J Eaves, None, Genetic and environmental factors in relative body weight and human adiposity. Behavior Genetics. ,vol. 27, pp. 325- 351 ,(1997) , 10.1023/A:1025635913927
Yi-Chun Loraine Tung, Giles S. H. Yeo, From GWAS to biology: lessons from FTO Annals of the New York Academy of Sciences. ,vol. 1220, pp. 162- 171 ,(2011) , 10.1111/J.1749-6632.2010.05903.X
Yi-Chun Loraine Tung, Eduard Ayuso, Xiaoye Shan, Fatima Bosch, Stephen O'Rahilly, Anthony P. Coll, Giles S. H. Yeo, Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats PLoS ONE. ,vol. 5, pp. e8771- ,(2010) , 10.1371/JOURNAL.PONE.0008771
Taku MASUYAMA, Yoshiaki KATSUDA, Masami SHINOHARA, A Novel Model of Obesity-Related Diabetes: Introgression of the Leprfa Allele of the Zucker Fatty Rat into Nonobese Spontaneously Diabetic Torii (SDT) Rats Experimental Animals. ,vol. 54, pp. 13- 20 ,(2005) , 10.1538/EXPANIM.54.13
C. M. K. MORROW, C. E. HOSTETLER, M. D. GRISWOLD, M.-C. HOFMANN, K. M. MURPHY, P. S. COOKE, R. A. HESS, ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood–testes barrier function and testicular immune privilege Annals of the New York Academy of Sciences. ,vol. 1120, pp. 144- 151 ,(2007) , 10.1196/ANNALS.1411.005
Satoshi Ugi, Yoshihiko Nishio, Hiroshi Yamamoto, Kazuhiro Ikeda, Masaaki Kobayashi, Shuichi Tsukada, Motoyuki Kondo, Katsutaro Morino, Toshiyuki Obata, Takeshi Yoshizaki, Takashi Uzu, Hiroyuki Naitoh, Toru Tani, Shiro Maeda, Atsunori Kashiwagi, Hiroshi Maegawa, Relation of the Expression of Transcriptional Factor TFAP2B to That of Adipokines in Subcutaneous and Omental Adipose Tissues Obesity. ,vol. 18, pp. 1277- 1282 ,(2010) , 10.1038/OBY.2009.442
Roger D Cone, The Central Melanocortin System and Energy Homeostasis Trends in Endocrinology and Metabolism. ,vol. 10, pp. 211- 216 ,(1999) , 10.1016/S1043-2760(99)00153-8
Albert J. Stunkard, A Twin Study of Human Obesity JAMA: The Journal of the American Medical Association. ,vol. 256, pp. 51- 54 ,(1986) , 10.1001/JAMA.1986.03380010055024
Michael Schäfer, Anja U. Bräuer, Nicolai E. Savaskan, Fritz G. Rathjen, Thomas Brümmendorf, Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion. Molecular and Cellular Neuroscience. ,vol. 29, pp. 580- 590 ,(2005) , 10.1016/J.MCN.2005.04.010