Relation of the Expression of Transcriptional Factor TFAP2B to That of Adipokines in Subcutaneous and Omental Adipose Tissues
作者： Satoshi Ugi , Yoshihiko Nishio , Hiroshi Yamamoto , Kazuhiro Ikeda , Masaaki Kobayashi
DOI: 10.1038/OBY.2009.442
关键词:
摘要: To determine the potential role of transcriptional factor-activating enhancer-binding protein-2β (TFAP2B) in regulation expression adipokines, adiponectin, leptin, and interleukin-6 (IL-6) vivo, we quantified mRNA levels these adipokines TFAP2B visceral (omental) abdominal subcutaneous adipose tissues 66 individuals with variable degree adiposity studied their correlations BMI plasma concentrations. We found that correlated negatively adiponectin positively those leptin. Adiponection fat BMI, whereas leptin omentum BMI. In contrast, IL-6 omental did not correlate levels. Whereas it tissue. Furthermore, both tissues. These relationships are consistent our vitro observations indicate seems to regulate various vivo.
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M. Cnop, P. J. Havel, K. M. Utzschneider, D. B. Carr, M. K. Sinha, E. J. Boyko, B. M. Retzlaff, R. H. Knopp, J. D. Brunzell, S. E. Kahn, Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia. ,vol. 46, pp. 459- 469 ,(2003) , 10.1007/S00125-003-1074-Z
Takashi Kadowaki, Kazuo Hara, Toshimasa Yamauchi, Yasuo Terauchi, Kazuyuki Tobe, Ryozo Nagai, Molecular mechanism of insulin resistance and obesity. Experimental Biology and Medicine. ,vol. 228, pp. 1111- 1117 ,(2003) , 10.1177/153537020322801003
Kazuhiro Ikeda, Hiroshi Maegawa, Satoshi Ugi, Yukari Tao, Yoshihiko Nishio, Shuichi Tsukada, Shiro Maeda, Atsunori Kashiwagi, Transcription Factor Activating Enhancer-binding Protein-2β A NEGATIVE REGULATOR OF ADIPONECTIN GENE EXPRESSION Journal of Biological Chemistry. ,vol. 281, pp. 31245- 31253 ,(2006) , 10.1074/JBC.M605132200
Shiro Maeda, Shuichi Tsukada, Akio Kanazawa, Akihiro Sekine, Tatsuhiko Tsunoda, Daisuke Koya, Hiroshi Maegawa, Atsunori Kashiwagi, Tetsuya Babazono, Masafumi Matsuda, Yasushi Tanaka, Tomoaki Fujioka, Hiroshi Hirose, Takashi Eguchi, Yoichi Ohno, Christopher J. Groves, Andrew T. Hattersley, Graham A. Hitman, Mark Walker, Kohei Kaku, Yasuhiko Iwamoto, Ryuzo Kawamori, Ryuichi Kikkawa, Naoyuki Kamatani, Mark I. McCarthy, Yusuke Nakamura, Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. Journal of Human Genetics. ,vol. 50, pp. 283- 292 ,(2005) , 10.1007/S10038-005-0253-9
Shuichi Tsukada, Yasushi Tanaka, Hiroshi Maegawa, Atsunori Kashiwagi, Ryuzo Kawamori, Shiro Maeda, Intronic polymorphisms within TFAP2B regulate transcriptional activity and affect adipocytokine gene expression in differentiated adipocytes Molecular Endocrinology. ,vol. 20, pp. 1104- 1111 ,(2006) , 10.1210/ME.2005-0311
John N. Fain, Atul K. Madan, M. Lloyd Hiler, Paramjeet Cheema, Suleiman W. Bahouth, Comparison of the Release of Adipokines by Adipose Tissue, Adipose Tissue Matrix, and Adipocytes from Visceral and Subcutaneous Abdominal Adipose Tissues of Obese Humans Endocrinology. ,vol. 145, pp. 2273- 2282 ,(2004) , 10.1210/EN.2003-1336
Mikako Degawa-Yamauchi, Katherine A. Moss, Jason E. Bovenkerk, Sudha S. Shankar, Charles L. Morrison, Christopher J. Lelliott, Antonio Vidal-Puig, RoseMarie Jones, Robert V. Considine, Regulation of Adiponectin Expression in Human Adipocytes: Effects of Adiposity, Glucocorticoids, and Tumor Necrosis Factor α Obesity Research. ,vol. 13, pp. 662- 669 ,(2005) , 10.1038/OBY.2005.74
Toshimitsu Yatagai, Shoichiro Nagasaka, Ataru Taniguchi, Mitsuo Fukushima, Tomoatsu Nakamura, Akira Kuroe, Yoshikatsu Nakai, Shun Ishibashi, Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus. Metabolism-clinical and Experimental. ,vol. 52, pp. 1274- 1278 ,(2003) , 10.1016/S0026-0495(03)00195-1
Marie-Claude Vohl, Rob Sladek, Julie Robitaille, Scott Gurd, Picard Marceau, Denis Richard, Thomas J. Hudson, André Tchernof, A survey of genes differentially expressed in subcutaneous and visceral adipose tissue in men Obesity Research. ,vol. 12, pp. 1217- 1222 ,(2004) , 10.1038/OBY.2004.153
Erin E. Kershaw, Jeffrey S. Flier, Adipose Tissue as an Endocrine Organ The Journal of Clinical Endocrinology and Metabolism. ,vol. 89, pp. 2548- 2556 ,(2004) , 10.1210/JC.2004-0395