Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus.
作者： Toshimitsu Yatagai , Shoichiro Nagasaka , Ataru Taniguchi , Mitsuo Fukushima , Tomoatsu Nakamura
DOI: 10.1016/S0026-0495(03)00195-1
关键词: Leptin 、 Insulin 、 Adiponectin 、 Type 2 Diabetes Mellitus 、 Type 2 diabetes 、 Medicine 、 Endocrinology 、 Pancreatic hormone 、 Internal medicine 、 Body mass index 、 Insulin resistance
摘要: Abstract The aim of the present study was to investigate association serum adiponectin concentration with regional adiposity and insulin resistance in subjects type 2 diabetes mellitus. A total 73 Japanese men (aged 59 ± 11 years body mass index [BMI] 23.8 3.0 kg/m , mean SD) were studied. Fasting leptin concentrations determined by radioimmunoassay. Regional measured abdominal computed tomography (CT) at umbilical level, estimated homeostasis model assessment (HOMA-R). Univariate regression analysis showed that levels negatively correlated subcutaneous visceral fat areas. With multivariate analysis, area a predominant determinant levels. In contrast, strongly associated concentrations. Among areas, BMI, levels, both areas independently HOMA-R. another incorporating selected as an independent HOMA-R instead area. conclusion, hypoadiponectinemia accumulation rather than depot Both contribute these subjects, contribution may be mediated, part, hypoadiponectinemia.
elsevier.com
sci-hub.se 参考文章(33)
Anders H. Berg, Terry P. Combs, Xueliang Du, Michael Brownlee, Philipp E. Scherer, The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nature Medicine. ,vol. 7, pp. 947- 953 ,(2001) , 10.1038/90992
T. Yamauchi, J. Kamon, H. Waki, Y. Terauchi, N. Kubota, K. Hara, Y. Mori, T. Ide, K. Murakami, N. Tsuboyama-Kasaoka, O. Ezaki, Y. Akanuma, O. Gavrilova, C. Vinson, M.L. Reitman, H. Kagechika, K. Shudo, M. Yoda, Y. Nakano, K. Tobe, R. Nagai, S. Kimura, M. Tomita, P. Froguel, T. Kadowaki, The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Nature Medicine. ,vol. 7, pp. 941- 946 ,(2001) , 10.1038/90984
L. Sjostrom, H. Kvist, A. Cederblad, U. Tylen, Determination of total adipose tissue and body fat in women by computed tomography, 40K, and tritium American Journal of Physiology-Endocrinology and Metabolism. ,vol. 250, pp. E736- E745 ,(1986) , 10.1152/AJPENDO.1986.250.6.E736
Yukio Arita, Shinji Kihara, Noriyuki Ouchi, Masahiko Takahashi, Kazuhisa Maeda, Jun-ichiro Miyagawa, Kikuko Hotta, Iichiro Shimomura, Tadashi Nakamura, Koji Miyaoka, Hiroshi Kuriyama, Makoto Nishida, Shizuya Yamashita, Kosaku Okubo, Kenji Matsubara, Masahiro Muraguchi, Yasuichi Ohmoto, Tohru Funahashi, Yuji Matsuzawa, Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communications. ,vol. 257, pp. 79- 83 ,(1999) , 10.1006/BBRC.1999.0255
M. A. Banerji, R. L. Chaiken, D. Gordon, J. G. Kral, H. E. Lebovitz, Does Intra-Abdominal Adipose Tissue in Black Men Determine Whether NIDDM Is Insulin-Resistant or Insulin-Sensitive? Diabetes. ,vol. 44, pp. 141- 146 ,(1995) , 10.2337/DIAB.44.2.141
Shoichiro Nagasaka, San-e Ishikawa, Tomoatsu Nakamura, Akio Kawakami, Kumiko Rokkaku, Hiroko Hayashi, Ikuyo Kusaka, Minori Higashiyama, Toshikazu Saito, Association of endogenous insulin secretion and mode of therapy with body fat and serum leptin levels in diabetic subjects. Metabolism-clinical and Experimental. ,vol. 47, pp. 1391- 1396 ,(1998) , 10.1016/S0026-0495(98)90311-0
Ataru Taniguchi, Yoshikatsu Nakai, Masahiko Sakai, Satoru Yoshii, Daizaburo Hamanaka, Yasuhiko Hatae, Mayumi Kawata, Kazufumi Yamanouchi, Takahide Okumura, Kentaro Doi, Kumpei Tokuyama, Shoichiro Nagasaka, Mitsuo Fukushima, Relationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients. Metabolism-clinical and Experimental. ,vol. 51, pp. 544- 548 ,(2002) , 10.1053/META.2002.31984
David E. Kelley, Katherine V. Williams, Julie C. Price, Therese M. McKolanis, Bret H. Goodpaster, F. Lee Thaete, Plasma Fatty Acids, Adiposity, and Variance of Skeletal Muscle Insulin Resistance in Type 2 Diabetes Mellitus The Journal of Clinical Endocrinology and Metabolism. ,vol. 86, pp. 5412- 5419 ,(2001) , 10.1210/JCEM.86.11.8027
Ataru Taniguchi, Mitsuo Fukushima, Masahiko Sakai, Kiyoshi Kataoka, Itaru Nagata, Kentaro Doi, Hiroaki Arakawa, Shoichiro Nagasaka, Kumpei Tokuyama, Yoshikatsu Nakai, The role of the body mass index and triglyceride levels in identifying insulin-sensitive and insulin-resistant variants in Japanese non-insulin-dependent diabetic patients. Metabolism-clinical and Experimental. ,vol. 49, pp. 1001- 1005 ,(2000) , 10.1053/META.2000.7735
E. Bonora, G. Targher, M. Alberiche, R. C. Bonadonna, F. Saggiani, M. B. Zenere, T. Monauni, M. Muggeo, Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care. ,vol. 23, pp. 57- 63 ,(2000) , 10.2337/DIACARE.23.1.57