Implications of Central Obesity-Related Variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on Quantitative Metabolic Traits in Adult Danes
作者： Dorthe S. Bille , Karina Banasik , Johanne M. Justesen , Camilla H. Sandholt , Annelli Sandbæk
DOI: 10.1371/JOURNAL.PONE.0020640
关键词: Methionine sulfoxide reductase 、 Genome-wide association study 、 MSRA 、 Type 2 diabetes 、 Overweight 、 Obesity 、 Genetic association 、 Endocrinology 、 Waist–hip ratio 、 Internal medicine 、 Biology 、 Genetics 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Background Two meta-analyses of genome-wide association studies (GWAS) have suggested that four variants: rs2605100 in lysophospholipase-like 1 (LYPLAL1), rs10146997 neuroxin 3 (NRXN3), rs545854 methionine sulfoxide reductase A (MSRA), and rs987237 transcription factor activating enhancer-binding protein 2 beta (TFAP2B) associate with measures central obesity. To elucidate potential underlying phenotypes we aimed to investigate whether these variants associated with: 1) quantitative metabolic traits, 2) anthropometric (waist circumference (WC), waist-hip ratio, BMI), or 3) type diabetes, general overweight obesity.
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