Attenuation of ischemia-induced regional myocardial acidosis by LP-805, a newly developed vasodilator, in dogs.
作者： Ichihara Kazuo , Morimoto Toshihiro , Shiba Toshiharu , Tsujitani Michihiko , Abiko Yasushi
DOI: 10.1016/0014-2999(91)90696-N
关键词:
摘要: Abstract The effect of 8-tert-butyl-6,7-dihydropyrrolo[3,2-e]-5-methyl-pyrazolo[l,5-a]pyrimidine-3-carbonitrile (LP-805), a newly developed vasodilator, on myocardial acidosis induced by ischemia was studied in anesthetized open-chest dogs. Ischemia partially occluding the left anterior descending coronary artery. flow artificially reduced to about 1 3 original flow. Myocardial pH measured with glass micro electrode inserted into ventricular wall perfused occluded decreased from 7.5 6.9 after onset and remained at this low level until artery released. After 30 min ischemia, either saline containing 0.1 N HCl or 10, 100 μg/kg LP-805 injected intravenously. attenuated decrease dose-dependent manner. In conclusion, may reduce influence myocardium.
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