Patent Update: Antihypertensive Agents: Recent Advances December 1991 through April 1992

E. Bellissant, C. Thuillez, R. Kechrid, P. Duhaze, J. F. Giudicelli, Non invasive study of systemic and regional haemodynamic and cardiac effects of a new calcium antagonist, SR 33557, in healthy volunteers European Journal of Clinical Pharmacology. ,vol. 41, pp. 329- 334 ,(1991) , 10.1007/BF00314962

Shoji Shibata, Nobuhiro Satake, Itsuo Kodama, R. Kelly Hester, Chang-Gen Wang, Hiroshi Jino, Masakazu Hojo, Hiroshi Tatsumi, Vijayalakshmi Gandhi, David J. Jones, Pharmacological characteristics of NP-252, a new dihydropyridine slow Ca2+ channel blocker, in isolated rabbit vascular smooth muscle and guinea pig myocardium: vascular selectivity European Journal of Pharmacology. ,vol. 203, pp. 337- 344 ,(1991) , 10.1016/0014-2999(91)90888-W

Timothy D. Ocain, David D. Deininger, Ralph Russo, Nancie A. Senko, Alan Katz, Jan M. Kitzen, Robert Mitchell, George Oshiro, Anthony Russo, New modified heterocyclic phenylalanine derivatives. Incorporation into potent inhibitors of human renin. Journal of Medicinal Chemistry. ,vol. 35, pp. 823- 832 ,(1992) , 10.1021/JM00083A005

David M. Floyd, S. David Kimball, John Krapcho, Jagabandhu Das, Chester F. Turk, Robert V. Moquin, Michael W. Lago, Keith J. Duff, Ving G. Lee, Benzazepinone calcium channel blockers. 2. Structure-activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones. Journal of Medicinal Chemistry. ,vol. 35, pp. 756- 772 ,(1992) , 10.1021/JM00082A018

Annette M. Doherty, Ila Sircar, Brian E. Kornberg, John Quin, R. Thomas Winters, James S. Kaltenbronn, Michael D. Taylor, Brian L. Batley, Stephen R. Rapundalo, Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors Journal of Medicinal Chemistry. ,vol. 35, pp. 2- 14 ,(1992) , 10.1021/JM00079A001

Kentaro Kogi, Takehiro Uchibori, Kazuyuki Aihara, Takahiro Yamaguchi, Toichi Abiru, Pharmacological profile of the 2-alkynyladenosine derivative 2-octynyladenosine (YT-146) in the cardiovascular system. Japanese Journal of Pharmacology. ,vol. 57, pp. 153- 165 ,(1991) , 10.1254/JJP.57.153

Ichihara Kazuo, Morimoto Toshihiro, Shiba Toshiharu, Tsujitani Michihiko, Abiko Yasushi, Attenuation of ischemia-induced regional myocardial acidosis by LP-805, a newly developed vasodilator, in dogs. European Journal of Pharmacology. ,vol. 204, pp. 127- 133 ,(1991) , 10.1016/0014-2999(91)90696-N

Toyokazu Takada, Nobuaki Miyawaki, Masaaki Kageyama, Kiyoshi Matsuno, Naruhiro Ishida, Hideyasu Yamauchi, Tadashi Iso, Antihypertensive effect of a novel calcium antagonist, SD-3211, in experimental hypertensive rats. Journal of Cardiovascular Pharmacology. ,vol. 18, pp. 855- 862 ,(1991) , 10.1097/00005344-199112000-00011

Valérie B. Schini, Paul M. Vanhoutte, Endothelin-1: a potent vasoactive peptide. Pharmacology & Toxicology. ,vol. 69, pp. 303- 309 ,(1991) , 10.1111/J.1600-0773.1991.TB01302.X

Osamu Kinoshita, Yuhei Kawano, Hiroki Yoshimi, Terunao Ashida, Kaoru Yoshida, Satoshi Akabane, Morio Kuramochi, Teruo Omae, Acute and chronic effects of anti-endothelin-1 antibody on blood pressure in spontaneously hypertensive rats Journal of Cardiovascular Pharmacology. ,vol. 17, ,(1991) , 10.1097/00005344-199100177-00146