Depresyon ve Nöroplastisite
作者： Levent Mete
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摘要: Neuroplasticity and depression The monoamine hypothesis claims that is a result of deficiency serotonin and/or noradrenaline in the neuronal synapses central nervous system. In recent years effectiveness explaining etiology by this has been critically examined. contribution disability neuroplasticity brain causation depressive disorder gained importance. an ability system to adapt changing world. It contributes functions learning, forgetting remembering. comprises structural functional changes neurons according impulses coming from inside outside body. article relationships some factors (LTP, LTD, sAMP, protein kinases, CREBP, BDNF) are reviewed. A relationship between disturbance suggested. Clarification these developments their may help develop new drugs future for treatment
psikofarmakoloji.org 参考文章(82)
Eberhard Fuchs, Gabriele Flügge, Cellular consequences of stress and depression. Dialogues in clinical neuroscience. ,vol. 6, pp. 171- 183 ,(2004)
Kamata H, Saito T, Maeda H, Ozawa H, Takahata N, Differential effects of chronic administration of the antidepressants amitriptyline and rolipram on adenylyl cyclase activity. Japanese journal of psychopharmacology. ,vol. 18, pp. 23- 25 ,(1998)
J. Thome, N. Sakai, K.-H. Shin, C. Steffen, Y.-J. Zhang, S. Impey, D. Storm, R. S. Duman, cAMP Response Element-Mediated Gene Transcription Is Upregulated by Chronic Antidepressant Treatment The Journal of Neuroscience. ,vol. 20, pp. 4030- 4036 ,(2000) , 10.1523/JNEUROSCI.20-11-04030.2000
Sari Lähteinen, Asla Pitkänen, Juha Knuuttila, Petri Törönen, Eero Castrén, Brain-derived neurotrophic factor signaling modifies hippocampal gene expression during epileptogenesis in transgenic mice. European Journal of Neuroscience. ,vol. 19, pp. 3245- 3254 ,(2004) , 10.1111/J.0953-816X.2004.03440.X
Francesco Angelucci, Aleksander A. Mathé, Luigi Aloe, Neurotrophic factors and CNS disorders: findings in rodent models of depression and schizophrenia Progress in Brain Research. ,vol. 146, pp. 151- 165 ,(2004) , 10.1016/S0079-6123(03)46011-1
S. D. Kuipers, A. Trentani, J. A. Den Boer, G. J. Ter Horst, Molecular correlates of impaired prefrontal plasticity in response to chronic stress Journal of Neurochemistry. ,vol. 85, pp. 1312- 1323 ,(2003) , 10.1046/J.1471-4159.2003.01770.X
Eiji Shimizu, Kenji Hashimoto, Naoe Okamura, Kaori Koike, Naoya Komatsu, Chikara Kumakiri, Michiko Nakazato, Hiroyuki Watanabe, Naoyuki Shinoda, Sin-ichi Okada, Masaomi Iyo, Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants Biological Psychiatry. ,vol. 54, pp. 70- 75 ,(2003) , 10.1016/S0006-3223(03)00181-1
Gayle M Wittenberg, Joe Z Tsien, An emerging molecular and cellular framework for memory processing by the hippocampus Trends in Neurosciences. ,vol. 25, pp. 501- 505 ,(2002) , 10.1016/S0166-2236(02)02231-2
Jessica Malberg, Lee Schechter, Increasing hippocampal neurogenesis: a novel mechanism for antidepressant drugs Current Pharmaceutical Design. ,vol. 11, pp. 145- 155 ,(2005) , 10.2174/1381612053382223
Shih-Jen Tsai, Down-regulation of the Trk-B signal pathway: the possible pathogenesis of major depression. Medical Hypotheses. ,vol. 62, pp. 215- 218 ,(2004) , 10.1016/S0306-9877(03)00299-8