Cellular consequences of stress and depression.

摘要: Stress is known to activate distinct neuronal circuits in the brain and induce multiple changes on cellular level, including alterations structures. On basis of clinical observations that stress often precipitates a depressive disease, chronic psychosocial serves as an experimental model evaluate molecular associated with consequences major depression. Antidepressants are presently believed exert their primary biochemical effects by readjusting aberrant intrasynaptic concentrations neurotransmitters, such serotonin or noradrenaline, suggesting imbalances viihin monoaminergic systems contribute disorder (monoaminergic hypothesis depression). Here, we reviev results comprise our understanding stressful experience processes, particular focus structural within target areas neurons.