Localized controlled release of stratifin reduces implantation-induced dermal fibrosis.

摘要: Localized controlled release of anti-fibrogenic factors can potentially prevent tissue fibrosis surrounding biomedical prostheses, such as vascular stents and breast implants. We have previously demonstrated that therapeutic intervention with topically applied stratifin in a rabbit ear fibrotic model not only prevents dermal but also promotes more normal repair by regulating extracellular matrix deposition. In this work, the effect form was investigated prevention induced poly(lactic-co-glycolic acid) (PLGA) microsphere/poly(vinyl alcohol) (PVA) hydrogel Pharmacodynamic effects were evaluated histopathological examination subcutaneous implanted composites. Controlled from PLGA microsphere/PVA implants significantly moderated inflammation reducing collagen deposition (30%), total cellularity (48%) infiltrated CD3+ immune cells (81%) compared stratifin-free The markedly increased level metalloproteinase-1 expression tissue, which resulted less These stratifin-eluting PLGA/PVA composites show promise coatings to decrease typical exhibited around stents.