Blood biomarkers of uveal melanoma metastasis.

摘要: The mortality for uveal melanoma remains high because of the development metastatic disease, predominantly in liver, that almost invariably is refractory to therapy. A potentially effective strategy would be suppress micrometastases before they progress. Systemic therapy may more adjuvant setting treating micro- rather than macrometastatic where several mechanisms resistance can develop. Likewise, earlier detection disease increase effectiveness already-existing therapies. Liver-function tests are routinely used detect asymptomatic liver metastasis. In patients with melanoma, have specificity and predictive values but a very low sensitivity.1 Genotyping primary tumour identify at risk metastasis becoming increasingly applied clinically.2 time from diagnosis discovery range weeks decades. Assessment tissue does not indicate whether cells actually been shed forming metastasis, it cannot treatment reducing Blood biomarkers needed. …