TIME COURSE OF PULMONARY RESPONSE OF RATS TO INHALATION OF CRYSTALLINE SILICA: NF-kappa B ACTIVATION, INFLAMMATION, CYTOKINE PRODUCTION, AND DAMAGE
作者： Jane Ma , Mark Barger , Victor A. Robinson , Dawn Ramsey , Jeff McLaurin
DOI: 10.1080/08958370252870998
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摘要: In vitro studies suggest that silica-induced lung disease may be linked to processes regulated by nuclear factor- κ B (NF- B) activation, but this has not been examined in vivo. Rats were exposed a silica aerosol of 15 mg/m 3 (6 h/day, 5 days/wk) for 116 days, and bronchoalveolar lavage (BAL) was conducted at various times during the exposure. Silica-induced pulmonary inflammation damage determined measuring BAL cell differentials first fluid lactate dehydrogenase (LDH) activity serum albumin concentrations, respectively. NF- activation production tumor necrosis factor-α (TNF-α) interleukin-1 (IL-1) cells also measured. The results demonstrate occurred after days exposure, continued increase thereafter. IL-1 TNF-α had increased incrementally 10 30 This elevation through 79 exposure before further increasing Pul...
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