Ceramics manufacturing contributes to ambient silica air pollution and burden of lung disease

作者: Chung-Min Liao , Bo-Chun Wu , Yi-Hsien Cheng , Shu-Han You , Yi-Jun Lin

DOI: 10.1007/S11356-015-4701-6

关键词:

摘要: Inhalation of silica (SiO2) in occupational exposures can cause pulmonary fibrosis (silicosis), lung function deficits, inflammation, and cancer. Current risk assessment models, however, cannot fully explain the magnitude silica-induced disease risk. The purpose this study was to assess human health exposed airborne dust Taiwan ceramics manufacturing. We conducted measurements characterize workplace-specific tile commodity ceramic factories used physiologically based alveolar exposure model estimate dose. constructed dose–response models for describing relationships between dose inflammatory responses, by which risks among workers be assessed. found that contents were 0.22–33.04 % with mean concentration ranges 0.11–5.48 0.46–1763.30 μg m−3, respectively, factories. showed granulation factory had highest total SiO2 burden (∼1000 mg) cumulative ∼4 × 104 mg-year. threshold estimates an effect on inflammation are 407.31 ± 277.10 (mean ± sd) 505.91 ± 231.69 mg, respectively. For workers, long-term 30–45 years likely pose severe adverse fibrosis. provide integrated algorithms required implement analyses maintain resulting at safety level hope they will stimulate further interpretation. suggest decision-makers take action platforms effective management prevent related

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