Assessing human exposure risk and lung disease burden posed by airborne silver nanoparticles emitted by consumer spray products.

摘要: Background No systematic investigations have been conducted to assess the lung burden imposed by chronic inhalation of silver nanoparticles (AgNPs) emitted spray products. Objective The objective this study was formulate a framework that integrates probabilistic risk assessment scheme with mechanistic model for estimation health risks associated long-term AgNP-containing Materials and methods A compartmentalized physiologically based alveolar deposition (PBAD) used estimate AgNP burden. Dose-response relationships were established using nanotoxicity data sets obtained from rats (as organism). Weibull model-based thresholds on neutrophil-elevated inflammation bio-markers estimated Hill-based exposure-response relationships. Finally, disease posed various products assessed. Results Conservative prevention pulmonary as follows (mean ± SE): 34 nm AgNPs (0.32±0.22 mg) 60 (1.08±0.64 mg). Our results indicate probability ~0.5 hazard quotient (HQ) estimates deodorant count median diameter (CMD) ≈30 exceeded 1. primary is transferred interstitial region lymph nodes. Under condition 50% probability, 97.5 percentile HQ follows: CMD (~3.4) ≈60 (~1.1). Conclusion application proposed in an vivo animal proved highly effective elucidating relationship between characteristics metallic NP-containing their corresponding toxicity. integration PBAD enables rapid containing NPs over time scales.