作者: Moritz N. Wente , Jörg Kleeff , Markus W. Büchler , Jantien Wanders , Peter Cheverton
DOI: 10.1007/S10637-005-1442-2
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摘要: Background: DE-310 is composed of the topoisomerase-I-inhibitor DX-8951 (exatecan) and a biodegradable macromolecular carrier, which are covalently linked by a peptidyl spacer. …