DE-310, a macromolecular prodrug of the topoisomerase-I-inhibitor exatecan (DX-8951), in patients with operable solid tumors.

作者: Moritz N. Wente , Jörg Kleeff , Markus W. Büchler , Jantien Wanders , Peter Cheverton

DOI: 10.1007/S10637-005-1442-2

关键词:

摘要: Background: DE-310 is composed of the topoisomerase-I-inhibitor DX-8951 (exatecan) and a biodegradable macromolecular carrier, which are covalently linked by a peptidyl spacer. …

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