Phase I study of topoisomerase I inhibitor exatecan mesylate (DX-8951f) given as weekly 24-hour infusions three of every four weeks.
作者： Nancy Kemeny , David Ilson , David Kelsen , Ellen Hollywood , Gary K. Schwartz
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摘要: Exatecan mesylate (DX-8951f) is a topoisomerase I inhibitor that has increased solubility and antitumor activity compared with other topoisomerase I inhibitors. The purpose of this study …
aacrjournals.org参考文章(17)
Y H Hsiang, R Hertzberg, S Hecht, L F Liu, Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. Journal of Biological Chemistry. ,vol. 260, pp. 14873- 14878 ,(1985) , 10.1016/S0021-9258(17)38654-4
M L Rothenberg, J R Eckardt, J G Kuhn, H A Burris, J Nelson, S G Hilsenbeck, G I Rodriguez, A M Thurman, L S Smith, S G Eckhardt, G R Weiss, G L Elfring, D A Rinaldi, L J Schaaf, D D Von Hoff, Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer. Journal of Clinical Oncology. ,vol. 14, pp. 1128- 1135 ,(1996) , 10.1200/JCO.1996.14.4.1128
Soichi Takiguchi, Eiji Kumazawa, Takao Shimazoe, Akiko Tohgo, Akira Kono, Antitumor Effect of DX‐8951, a Novel Camptothecin Analog, on Human Pancreatic Tumor Cells and Their CPT‐11‐resistant Variants Cultured in vitro and Xenografted into Nude Mice Japanese Journal of Cancer Research. ,vol. 88, pp. 760- 769 ,(1997) , 10.1111/J.1349-7006.1997.TB00448.X
Ikuo Mitsui, Eiji Kumazawa, Yasuhide Hirota, Masashi Aonuma, Masamichi Sugimori, Satoru Ohsuki, Kouichi Uoto, Akio Ejima, Hirofumi Terasawa, Keiki Sato, A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Japanese Journal of Cancer Research. ,vol. 86, pp. 776- 782 ,(1995) , 10.1111/J.1349-7006.1995.TB02468.X
David Z D'argenio, Alan Schumitzky, A program package for simulation and parameter estimation in pharmacokinetic systems Computer Programs in Biomedicine. ,vol. 9, pp. 115- 134 ,(1979) , 10.1016/0010-468X(79)90025-4
Howard L. McLeod, Fiona Douglas, Melanie Oates, R. Paul Symonds, Drew Prakash, Ate G. J. Van Der Zee, Stanley B. Kaye, Robert Brown, W. Nicol Keith, Topoisomerase I and II activity in human breast, cervix, lung and colon cancer. International Journal of Cancer. ,vol. 59, pp. 607- 611 ,(1994) , 10.1002/IJC.2910590506
W. J. Slichenmyer, E. K. Rowinsky, R. C. Donehower, S. H. Kaufmann, The Current Status of Camptothecin Analogues as Antitumor Agents Journal of the National Cancer Institute. ,vol. 85, pp. 271- 291 ,(1993) , 10.1093/JNCI/85.4.271
B. Giovanella, J. Stehlin, M. Wall, M. Wani, A. Nicholas, L. Liu, R Silber, M Potmesil, DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts Science. ,vol. 246, pp. 1046- 1048 ,(1989) , 10.1126/SCIENCE.2555920
H Hollema, E G de Vries, J G Zijlstra, A Gouw, H Boonstra, Steven de Jong, P H Willemse, S de Jong, A G van der Zee, P-Glycoprotein Expression and DNA Topoisomerase I and II Activity in Benign Tumors of the Ovary and in Malignant Tumors of the Ovary, before and after Platinum/Cyclophosphamide Chemotherapy Cancer Research. ,vol. 51, pp. 5915- 5920 ,(1991)
L F Liu, DNA topoisomerase poisons as antitumor drugs. Annual Review of Biochemistry. ,vol. 58, pp. 351- 375 ,(1989) , 10.1146/ANNUREV.BI.58.070189.002031