Hand powered, cost effective, 3D printed nanoparticle synthesizer: effects of polymer end caps, drugs, and solvents on lipid polymer hybrid nanoparticles
作者： Lan Le , Anuja Bokare , Folarin Erogbogbo
关键词:
摘要: Lipid polymer hybrid nanoparticles (LPHNPs) consisting of PLGA variation as the core and DSPE-PEG a lipid shell have been synthesized by nanoprecipitation method using hand powered, 3D printed Multi Inlet Vortex Mixer (MIVM). This is relatively fast, simple cost-effective compared to other methods used for synthesis LPHNPs. Considering importance particle size in nanoparticle mediated drug delivery, LPHNPs with desired has attempted examining various formulation variables. The conditions such end caps, loading, amount organic solvent type optimized obtain size. formation core-shell like structure confirmed TEM analysis. resulting were proven long term stability controlled release properties.
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