Genomic Applications in Colorectal and Pancreatic Tumors

摘要: Colorectal cancer is one of the most common tumors in Western world. Prior groundbreaking findings based on meticulous single gene analysis colorectal elucidated progression from adenoma to invasive carcinoma a multistep process driven by accumulation mutations tumor suppressor genes (APC, p53, SMAD4) and oncogenes (KRAS). More recent high-throughput molecular genomic techniques confirmed model majority sporadic cancers whereas smaller subgroup develop via different route, mostly initiated mutation BRAF oncogene, that results oncogene-induced senescence (OIS) development methylator phenotype CIMP (CpG island phenotype). Next-generation sequencing enables more robust classification cancer, as well pancreatic cancer. As better understanding genetic alterations emerges, it becoming clear new molecular-based possible. This would complement morphologic system has been developed tested integrates morphology into cohesive with prognostic therapeutic implications.