A simple immunohistochemical algorithm predicts the risk of distant metastases in right-sided colon cancer.
作者： Jens Neumann , David Horst , Lydia Kriegl , Susanne Maatz , Jutta Engel
DOI: 10.1111/J.1365-2559.2011.04126.X
关键词: Sample size determination 、 Colorectal cancer 、 Medicine 、 Cancer stem cell 、 Metastasis 、 Microsatellite instability 、 MLH1 、 Immunohistochemistry 、 Risk assessment 、 Algorithm
摘要: Neumann J, Horst D, Kriegl L, Maatz S, Engel Jung A & Kirchner T (2012) Histopathology 60, 416–426 simple immunohistochemical algorithm predicts the risk of distant metastases in right-sided colon cancer Aims: test predicting would be valuable for prognostication cancer (CC). In previous studies, CC with microsatellite instability (MSI) showed a reduced metastases. High expression CD133 and β-catenin, both related to stem cell phenotypes, might predictive markers metastasis. The aim this study was develop robust assessment CC. Methods results: case–control study, 57 cases specimens synchronous were matched without Immunohistochemistry MLH1, nuclear β-catenin carried out. To define diagnostic tumours first stratified according their MLH1 expression. Loss correlated significantly very low (5.3%; P = 0.00003). MLH1-positive cases, combined high scores associated rate (94.4%), whereas intermediate carcinomas either and/or (P = 0.0007). validation using an independent set 68 clear trend towards stratification algorithm; however, sample sizes small, associations not statistically significant. Conclusions: By use three markers, allowed identification subgroups patients extremely
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