作者: Yunru Wang , Peng Xu , Yang Wang , Haiyan Liu , Yuwen Zhou
DOI: 10.1155/2013/507832
关键词:
摘要: Objective. To investigate the protection of salidroside heart against acute exhaustive injury and its mechanism antioxidative stress MAPKs signal transduction. Method. Adult male SD rats were divided into four groups randomly. Cardiomyocytes ultrastructure was observed by optical microscopy transmission electron microscopy. The contents CK, CK-MB, LDH, MDA, SOD determined ELISA method, phosphorylation degrees ERK p38 MAPK assayed Western blotting. Cardiac function isolated rat ischemia/reperfusion detected Langendorff technique. Results. Salidroside reduced myocardium caused swimming, decreased improved LVDP, ±LV / under basic condition, content MDA degree MAPK, increased in rats. Conclusion. has injury. cardioprotection is mainly mediated transduction through reducing increasing SOD, p-ERK decreasing p-p38 protein expressions myocardium, which might be mechanisms cardioprotective effect salidroside.