The protection of salidroside of the heart against acute exhaustive injury and molecular mechanism in rat.

作者: Yunru Wang , Peng Xu , Yang Wang , Haiyan Liu , Yuwen Zhou

DOI: 10.1155/2013/507832

关键词:

摘要: Objective. To investigate the protection of salidroside heart against acute exhaustive injury and its mechanism antioxidative stress MAPKs signal transduction. Method. Adult male SD rats were divided into four groups randomly. Cardiomyocytes ultrastructure was observed by optical microscopy transmission electron microscopy. The contents CK, CK-MB, LDH, MDA, SOD determined ELISA method, phosphorylation degrees ERK p38 MAPK assayed Western blotting. Cardiac function isolated rat ischemia/reperfusion detected Langendorff technique. Results. Salidroside reduced myocardium caused swimming, decreased improved LVDP, ±LV / under basic condition, content MDA degree MAPK, increased in rats. Conclusion. has injury. cardioprotection is mainly mediated transduction through reducing increasing SOD, p-ERK decreasing p-p38 protein expressions myocardium, which might be mechanisms cardioprotective effect salidroside.

参考文章(17)
Tian-Hua YAN, Bao-Sheng DU, Wei YANG, Ying MA, Jing XU, Qiu-Juan WANG, Effects of Salidroside on Hemorheology and Myocardial Ischemic Reperfusion Injury in Isolated Heart of Rats Chinese Journal of Natural Medicines. ,vol. 6, pp. 219- 222 ,(2008) , 10.1016/S1875-5364(09)60021-2
Z. Li, O. H. Bing, X. Long, K. G. Robinson, E. G. Lakatta, Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 272, ,(1997) , 10.1152/AJPHEART.1997.272.5.H2313
Jian-Guo Zhuang, Zhao-Nian Zhou, Protective Effects of Intermittent Hypoxic Adaptation on Myocardium and Its Mechanisms Neurosignals. ,vol. 8, pp. 316- 322 ,(1999) , 10.1159/000014602
Wataru Aoi, Yuji Naito, Kunihiro Sakuma, Masashi Kuchide, Harukuni Tokuda, Takashi Maoka, Shinya Toyokuni, Shigenori Oka, Masahiro Yasuhara, Toshikazu Yoshikawa, None, Astaxanthin Limits Exercise-Induced Skeletal and Cardiac Muscle Damage in Mice Antioxidants & Redox Signaling. ,vol. 5, pp. 139- 144 ,(2003) , 10.1089/152308603321223630
Atsushi Matsuzawa, Hidenori Ichijo, Stress-responsive protein kinases in redox-regulated apoptosis signaling. Antioxidants & Redox Signaling. ,vol. 7, pp. 472- 481 ,(2005) , 10.1089/ARS.2005.7.472
JIANSHENG XU, YING LI, Effects of salidroside on exhaustive exercise‑induced oxidative stress in rats Molecular Medicine Reports. ,vol. 6, pp. 1195- 1198 ,(2012) , 10.3892/MMR.2012.1060
D. PAUL THOMAS, Effects of acute and chronic exercise on myocardial ultrastructure. Medicine and Science in Sports and Exercise. ,vol. 17, pp. 546- ,(1985) , 10.1249/00005768-198510000-00007
L. L. JI, M‐C. GOMEZCABRERA, N. STEINHAFEL, J. VINA, Acute exercise activates nuclear factor (NF)-κB signaling pathway in rat skeletal muscle The FASEB Journal. ,vol. 18, pp. 1499- 1506 ,(2004) , 10.1096/FJ.04-1846COM