THE CELLULAR AND MOLECULAR BASIS FOR GROWTH HORMONE ACTION ON THE HEART

摘要: Despite a series of elegant studies perfonned by Beznak in the fifties clearly demonstrating Growth Honnone (GH)'s role maintaining nonnal hypertrophic response following experimental aortic constriction (1-3), cardiovascular GHlIGF-1 axis was largely overlooked. In fact, until few years ago, GH classically regarded as principal mediator bone linear growth, addition to its well known actions on glucose homeostasis and skeletal muscle mass, heart not generally considered target tissue (4). It is now established that only does play an essential cardiac mass function, but also growth-promoting positive inotropic may be beneficial setting failure ischemic syndromes.